Current Research Directions

Publications

  • TSG6 hyaluronan matrix remodeling dampens the inflammatory response during colitis

    Learn More Here

  • The role of hyaluronan synthesis and degradation in the critical respiratory illness COVID-19

    Learn More Here

  • COVID-19 generates hyaluronan fragments that directly induce endothelial barrier dysfunction

    Learn More Here

  • Hyaluronan and Its Receptors as Regulatory Molecules of the Endothelial Interface

    Learn More Here

  • Platelet Dysregulation in the Pathobiology of COVID-19

    Learn More Here

  • Heparanase expression and activity are increased in platelets during clinical sepsis

    Learn More Here

  • Cytokine release syndrome in COVID-19: Innate immune, vascular, and platelet pathogenic factors differ in severity of disease and sex

    Learn More Here

  • Platelet hyaluronidase-2 regulates the early stages of inflammatory disease in colitis

    Learn More Here

  • Thrombin Cleavage of Inter-α-inhibitor Heavy Chain 1 Regulates Leukocyte Binding to an Inflammatory Hyaluronan Matrix

    Learn More Here

  • Platelet Hyaluronan Synthase 3 Regulates Thrombin Signaling and Adhesion to Fibrinogen Under Venous Shear

    Learn More Here

Foundational Publications

  • TNFα impairs platelet function by inhibiting autophagy and disrupting metabolism via Syntaxin-17 downregulation

    Paper Link Here

  • Neonatal NET-inhibitory factor inhibits macrophage extracellular trap formation.

    Paper Link Here

  • A systemic sclerosis disease model: can inducible pluripotent stem cells fill an unmet need in defining vascular leak?

    Paper Link Here

  • Corrigendum: Neonatal NET-Inhibitory Factor improves survival in the cecal ligation and puncture model of polymicrobial sepsis by inhibiting neutrophil extracellular traps

    Paper Link Here

  • CD11c+ myeloid cell exosomes reduce intestinal inflammation during colitis

    Paper Link Here

  • COVID-19 patients exhibit reduced procoagulant platelet responses

    Paper Link Here

  • Editorial: Proteoglycans and Glycosaminoglycan Modification in Immune Regulation and Inflammation

    Paper Link Here

  • Platelet gene expression and function in patients with COVID-19

    Paper Link Here

  • Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome

    Paper Link Here

  • Hyaluronan in inflammatory bowel disease: Cross-linking inflammation and coagulation

    Paper Link Here

  • Multifunctional Role of 35 Kilodalton Hyaluronan in Promoting Defense of the Intestinal Epithelium

    Paper Link Here

  • Layilin is critical for mediating hyaluronan 35kDa-induced intestinal epithelial tight junction protein ZO-1 in vitro and in vivo

    Paper Link Here

  • The extracellular matrix in IBD: a dynamic mediator of inflammation

    Paper Link Here

  • Enzyme-specific differences in mannose phosphorylation between GlcNAc-1-phosphotransferase αβ and γ subunit deficient zebrafish support cathepsin proteases as early mediators of mucolipidosis pathology

    Paper Link Here

  • Hyaluronan Depolymerization by Megakaryocyte Hyaluronidase-2 Is Required for Thrombopoiesis

    Paper Link Here

  • Cathepsin-Mediated Alterations in TGFß-Related Signaling Underlie Disrupted Cartilage and Bone Maturation Associated With Impaired Lysosomal Targeting

    Paper Link Here

  • Hyaluronan, a crucial regulator of inflammation

    Paper Link Here

  • Excessive activity of cathepsin K is associated with cartilage defects in a zebrafish model of mucolipidosis II

    Paper Link Here

Additional Bibliography

Foundational Research for The Pretrey Lab’s Current Scientific Inquiries

  1. Rojas-Sanchez G, Calzada-Martinez J, McMahon B, Petrey AC, Dveksler G, Espino-Solis GP, Esparza O, Hernandez G, Le D, Wartchow EP, Jones K, Ting LH, Jankowski C, Kelher MR, Manco-Johnson M, Feser ML, Deane KD, Nemkov T, D'Alessandro A, Thorburn A, Maycotte P, López JA, Davizon-Castillo P. TNFα impairs platelet function by inhibiting autophagy and disrupting metabolism via Syntaxin-17 downregulation. J Clin Invest. 2025 Jun 10;. doi: 10.1172/JCI186065. [Epub ahead of print] PubMed PMID: 40493419.

  2. Bircher JS, Denorme F, Cody MJ, de Araujo CV, Petrey AC, Middleton EA, Campbell RA, Yost CC. Neonatal NET-inhibitory factor inhibits macrophage extracellular trap formation. Blood Adv. 2024 Jul 23;8(14):3686-3690. doi: 10.1182/bloodadvances.2024013094. PubMed PMID: 38810257; PubMed Central PMCID: PMC11284700.

  3. Frech TM, Maguire C, Petrey AC, Stoddard GJ, Donato AJ. A systemic sclerosis disease model: can inducible pluripotent stem cells fill an unmet need in defining vascular leak?. Rheumatology (Oxford). 2023 Jul 5;62(7):e226-e228. doi: 10.1093/rheumatology/keac719. PubMed PMID: 36575990; PubMed Central PMCID: PMC10321079.

  4. de Araujo CV, Denorme F, Stephens WZ, Li Q, Cody MJ, Crandell JL, Petrey AC, Queisser KA, Rustad JL, Fulcher JM, Evangelista JL, Kay MS, Schiffman JD, Campbell RA, Yost CC. Corrigendum: Neonatal NET-Inhibitory Factor improves survival in the cecal ligation and puncture model of polymicrobial sepsis by inhibiting neutrophil extracellular traps. Front Immunol. 2023;14:1171222. doi: 10.3389/fimmu.2023.1171222. eCollection 2023. PubMed PMID: 37063850; PubMed Central PMCID: PMC10091279.

  5. Bauer KM, Nelson MC, Tang WW, Chiaro TR, Brown DG, Ghazaryan A, Lee SH, Weis AM, Hill JH, Klag KA, Tran VB, Thompson JW, Ramstead AG, Monts JK, Marvin JE, Alexander M, Voth WP, Stephens WZ, Ward DM, Petrey AC, Round JL, O'Connell RM. CD11c+ myeloid cell exosomes reduce intestinal inflammation during colitis. JCI Insight. 2022 Oct 10;7(19). doi: 10.1172/jci.insight.159469. PubMed PMID: 36214220; PubMed Central PMCID: PMC9675566.

  6. Denorme F, Manne BK, Portier I, Petrey AC, Middleton EA, Kile BT, Rondina MT, Campbell RA. COVID-19 patients exhibit reduced procoagulant platelet responses. J Thromb Haemost. 2020 Nov;18(11):3067-3073. doi: 10.1111/jth.15107. Epub 2020 Oct 6. PubMed PMID: 32945081; PubMed Central PMCID: PMC7646270.

  7. Reijmers RM, Troeberg L, Lord MS, Petrey AC. Editorial: Proteoglycans and Glycosaminoglycan Modification in Immune Regulation and Inflammation. Front Immunol. 2020;11:595867. doi: 10.3389/fimmu.2020.595867. eCollection 2020. PubMed PMID: 33178227; PubMed Central PMCID: PMC7593530.

  8. Manne BK, Denorme F, Middleton EA, Portier I, Rowley JW, Stubben C, Petrey AC, Tolley ND, Guo L, Cody M, Weyrich AS, Yost CC, Rondina MT, Campbell RA. Platelet gene expression and function in patients with COVID-19. Blood. 2020 Sep 10;136(11):1317-1329. doi: 10.1182/blood.2020007214. PubMed PMID: 32573711; PubMed Central PMCID: PMC7483430.

  9. Middleton EA, He XY, Denorme F, Campbell RA, Ng D, Salvatore SP, Mostyka M, Baxter-Stoltzfus A, Borczuk AC, Loda M, Cody MJ, Manne BK, Portier I, Harris ES, Petrey AC, Beswick EJ, Caulin AF, Iovino A, Abegglen LM, Weyrich AS, Rondina MT, Egeblad M, Schiffman JD, Yost CC. Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome. Blood. 2020 Sep 3;136(10):1169-1179. doi: 10.1182/blood.2020007008. PubMed PMID: 32597954; PubMed Central PMCID: PMC7472714.

  10. Petrey AC, de la Motte CA. Hyaluronan in inflammatory bowel disease: Cross-linking inflammation and coagulation. Matrix Biol. 2019 May;78-79:314-323. doi: 10.1016/j.matbio.2018.03.011. Epub 2018 Mar 21. Review. PubMed PMID: 29574062; PubMed Central PMCID: PMC6150849.

  11. Kessler SP, Obery DR, Nickerson KP, Petrey AC, McDonald C, de la Motte CA. Multifunctional Role of 35 Kilodalton Hyaluronan in Promoting Defense of the Intestinal Epithelium. J Histochem Cytochem. 2018 Apr;66(4):273-287. doi: 10.1369/0022155417746775. Epub 2018 Jan 1. PubMed PMID: 29290146; PubMed Central PMCID: PMC5958379.

  12. Kim Y, West GA, Ray G, Kessler SP, Petrey AC, Fiocchi C, McDonald C, Longworth MS, Nagy LE, de la Motte CA. Layilin is critical for mediating hyaluronan 35kDa-induced intestinal epithelial tight junction protein ZO-1 in vitro and in vivo. Matrix Biol. 2018 Mar;66:93-109. doi: 10.1016/j.matbio.2017.09.003. Epub 2017 Oct 1. PubMed PMID: 28978412; PubMed Central PMCID: PMC5845474.

  13. Petrey AC, de la Motte CA. The extracellular matrix in IBD: a dynamic mediator of inflammation. Curr Opin Gastroenterol. 2017 Jul;33(4):234-238. doi: 10.1097/MOG.0000000000000368. Review. PubMed PMID: 28562487; PubMed Central PMCID: PMC5562400.

  14. Flanagan-Steet H, Matheny C, Petrey A, Parker J, Steet R. Enzyme-specific differences in mannose phosphorylation between GlcNAc-1-phosphotransferase αβ and γ subunit deficient zebrafish support cathepsin proteases as early mediators of mucolipidosis pathology. Biochim Biophys Acta. 2016 Sep;1860(9):1845-53. doi: 10.1016/j.bbagen.2016.05.029. Epub 2016 May 27. PubMed PMID: 27241848; PubMed Central PMCID: PMC4949139.

  15. Petrey AC, Obery DR, Kessler SP, Flamion B, de la Motte CA. Hyaluronan Depolymerization by Megakaryocyte Hyaluronidase-2 Is Required for Thrombopoiesis. Am J Pathol. 2016 Sep;186(9):2390-403. doi: 10.1016/j.ajpath.2016.05.004. Epub 2016 Jul 8. PubMed PMID: 27398974; PubMed Central PMCID: PMC5012466.

  16. Flanagan-Steet H, Aarnio M, Kwan B, Guihard P, Petrey A, Haskins M, Blanchard F, Steet R. Cathepsin-Mediated Alterations in TGFß-Related Signaling Underlie Disrupted Cartilage and Bone Maturation Associated With Impaired Lysosomal Targeting. J Bone Miner Res. 2016 Mar;31(3):535-48. doi: 10.1002/jbmr.2722. Epub 2015 Oct 13. PubMed PMID: 26404503; PubMed Central PMCID: PMC4808492.

  17. Petrey AC, de la Motte CA. Hyaluronan, a crucial regulator of inflammation. Front Immunol. 2014;5:101. doi: 10.3389/fimmu.2014.00101. eCollection 2014. Review. PubMed PMID: 24653726; PubMed Central PMCID: PMC3949149.

  18. Petrey AC, Flanagan-Steet H, Johnson S, Fan X, De la Rosa M, Haskins ME, Nairn AV, Moremen KW, Steet R. Excessive activity of cathepsin K is associated with cartilage defects in a zebrafish model of mucolipidosis II. Dis Model Mech. 2012 Mar;5(2):177-90. doi: 10.1242/dmm.008219. Epub 2011 Nov 1. PubMed PMID: 22046029; PubMed Central PMCID: PMC3291639.